oldSchoolBulker
New member
Before you continue reading:
This thread is NOT for:
1. Those assuming I'm promoting products: I've been involved in GH discussions for a long time and have helped many people with detailed advice, whether they’re using my products or not. If you’ve messaged me, you know I don’t push products but aim to educate.
2. Those who can’t follow basic rules: This includes flaming, name-calling, or mentioning specific sources that could lead to drama. The mods have been cleaning up enough mess lately—let’s keep it civil.
This thread is for:
Mature individuals who are genuinely interested in learning and contributing to a productive discussion.
Let's get started…
"I pinned 10 IUs of GH before my blood test, and the results show a high GH serum level! My GH is legit!"
Uh, hold on—there may be more to the story.
What’s really happening?
Recombinant DNA (rDNA) technology has made possible the development of protein-based drugs like human growth hormone (GH), insulin, and other biopharmaceuticals. The potency and effectiveness of these drugs depend on their chemical structure, and conventional analytical methods often fail to fully assess protein-based drugs. GH, being a large, flexible protein, can undergo structural changes that affect its biological activity.
What does this mean for GH testing?
The standard GH serum test typically measures only the concentration of the GH molecule. This doesn’t tell you if it’s biologically active. So, even if you have a high GH serum reading, it could mean your GH is:
- Non-bioactive
- Partially bioactive
- Fully bioactive
What about mass spectrometry?
Mass spectrometry can give us an idea of the molecular weight of the GH, but it doesn’t tell us if the protein is folded correctly or if it will actually bind to receptors and be biologically active. A molecule with the correct weight doesn’t necessarily mean it’s effective.
Is GH serum testing useless?
Not entirely. If your GH serum is low or within a typical range, it’s a good indicator that the GH is either inactive or not properly dosed. But if it’s high, you can’t be sure if it’s working as expected.
So, how can we truly test GH?
IGF-1 Testing:
The best way to assess whether GH is biologically active is to test for IGF-1 (Insulin-like Growth Factor 1). Real GH binds to receptors in the liver, stimulating IGF-1 production, which rises gradually over several weeks. Your best bet is to get an IGF-1 test 3+ weeks after starting a GH cycle. For a more accurate baseline, it’s recommended to test IGF-1 before starting your GH cycle.
Some also suggest testing IGF-1 a few days after your last shot, as IGF-1 levels tend to remain stable for a while.
Yes, this process can be tedious and expensive, but unfortunately, there is no shortcut to knowing whether your GH is working. Unless someone else has tested the same batch, you’ll need to do it yourself.
"But my GH serum was high, and I’ve been getting GH sides like water retention and sleepiness! How can it be non-bioactive?"
GH Sides vs. Real GH:
First, if you're calling these "GH sides," you’re likely misinformed. Real GH, when dosed correctly and ramped up gradually, is generally free from side effects. What you might be experiencing could actually be from other substances like DSIP (Delta Sleep-Inducing Peptide) or ADH (Anti-Diuretic Hormone), both of which can mimic GH sides.
"So, what should I buy?"
The safest and most reliable option is Pharma Grade GH. This is the only guarantee that you’re getting real GH, though be cautious—counterfeit pharma GH is not unheard of.
Generics:
Occasionally, high-quality generics can be found. The safest approach is to buy from a trusted source that has tested the batch thoroughly. However, generics may still be underdosed or have inconsistent quality, so there’s always a level of risk.
But generics work sometimes!
Yes, generics can work, but they are less predictable than pharma-grade GH. If you decide to try a generic, be prepared for variability in effectiveness. Always check reviews and lab tests from experienced users.
A few important takeaways:
1. Pharma-grade GH is the most reliable, but it’s also the most expensive.
2. Generics can work but may not always be bioactive or consistently dosed.
3. GH serum tests give you a rough idea, but you really need an IGF-1 test to assess effectiveness.
4. The molecular weight of GH from a mass spec doesn’t tell you if the protein is bioactive.
5. Rips GH often shows unusually high serum readings (40-60+), which can be a red flag for inconsistent quality.
Remember, GH testing is complex, and while there’s no one-size-fits-all solution, understanding the science behind it will help you make better decisions.
Final thoughts:
Legitimate pharma-grade GH typically shows a serum level between 20-35 following a 10 IU injection. If you’re seeing consistently higher readings (like 50+), this could indicate something off with the product.
Also, everyone’s response to GH is different—don’t just go by someone else’s test results. Your experience may differ based on many factors, including dosage, frequency, and individual body response.
This thread is NOT for:
1. Those assuming I'm promoting products: I've been involved in GH discussions for a long time and have helped many people with detailed advice, whether they’re using my products or not. If you’ve messaged me, you know I don’t push products but aim to educate.
2. Those who can’t follow basic rules: This includes flaming, name-calling, or mentioning specific sources that could lead to drama. The mods have been cleaning up enough mess lately—let’s keep it civil.
This thread is for:
Mature individuals who are genuinely interested in learning and contributing to a productive discussion.
Let's get started…
"I pinned 10 IUs of GH before my blood test, and the results show a high GH serum level! My GH is legit!"
Uh, hold on—there may be more to the story.
What’s really happening?
Recombinant DNA (rDNA) technology has made possible the development of protein-based drugs like human growth hormone (GH), insulin, and other biopharmaceuticals. The potency and effectiveness of these drugs depend on their chemical structure, and conventional analytical methods often fail to fully assess protein-based drugs. GH, being a large, flexible protein, can undergo structural changes that affect its biological activity.
What does this mean for GH testing?
The standard GH serum test typically measures only the concentration of the GH molecule. This doesn’t tell you if it’s biologically active. So, even if you have a high GH serum reading, it could mean your GH is:
- Non-bioactive
- Partially bioactive
- Fully bioactive
What about mass spectrometry?
Mass spectrometry can give us an idea of the molecular weight of the GH, but it doesn’t tell us if the protein is folded correctly or if it will actually bind to receptors and be biologically active. A molecule with the correct weight doesn’t necessarily mean it’s effective.
Is GH serum testing useless?
Not entirely. If your GH serum is low or within a typical range, it’s a good indicator that the GH is either inactive or not properly dosed. But if it’s high, you can’t be sure if it’s working as expected.
So, how can we truly test GH?
IGF-1 Testing:
The best way to assess whether GH is biologically active is to test for IGF-1 (Insulin-like Growth Factor 1). Real GH binds to receptors in the liver, stimulating IGF-1 production, which rises gradually over several weeks. Your best bet is to get an IGF-1 test 3+ weeks after starting a GH cycle. For a more accurate baseline, it’s recommended to test IGF-1 before starting your GH cycle.
Some also suggest testing IGF-1 a few days after your last shot, as IGF-1 levels tend to remain stable for a while.
Yes, this process can be tedious and expensive, but unfortunately, there is no shortcut to knowing whether your GH is working. Unless someone else has tested the same batch, you’ll need to do it yourself.
"But my GH serum was high, and I’ve been getting GH sides like water retention and sleepiness! How can it be non-bioactive?"
GH Sides vs. Real GH:
First, if you're calling these "GH sides," you’re likely misinformed. Real GH, when dosed correctly and ramped up gradually, is generally free from side effects. What you might be experiencing could actually be from other substances like DSIP (Delta Sleep-Inducing Peptide) or ADH (Anti-Diuretic Hormone), both of which can mimic GH sides.
"So, what should I buy?"
The safest and most reliable option is Pharma Grade GH. This is the only guarantee that you’re getting real GH, though be cautious—counterfeit pharma GH is not unheard of.
Generics:
Occasionally, high-quality generics can be found. The safest approach is to buy from a trusted source that has tested the batch thoroughly. However, generics may still be underdosed or have inconsistent quality, so there’s always a level of risk.
But generics work sometimes!
Yes, generics can work, but they are less predictable than pharma-grade GH. If you decide to try a generic, be prepared for variability in effectiveness. Always check reviews and lab tests from experienced users.
A few important takeaways:
1. Pharma-grade GH is the most reliable, but it’s also the most expensive.
2. Generics can work but may not always be bioactive or consistently dosed.
3. GH serum tests give you a rough idea, but you really need an IGF-1 test to assess effectiveness.
4. The molecular weight of GH from a mass spec doesn’t tell you if the protein is bioactive.
5. Rips GH often shows unusually high serum readings (40-60+), which can be a red flag for inconsistent quality.
Remember, GH testing is complex, and while there’s no one-size-fits-all solution, understanding the science behind it will help you make better decisions.
Final thoughts:
Legitimate pharma-grade GH typically shows a serum level between 20-35 following a 10 IU injection. If you’re seeing consistently higher readings (like 50+), this could indicate something off with the product.
Also, everyone’s response to GH is different—don’t just go by someone else’s test results. Your experience may differ based on many factors, including dosage, frequency, and individual body response.