Some basics about HGH p.1

chrisTheChemist

chrisTheChemist

Member
Hello to new strenddit fam! Wanted to share with all my new HGH guide. Today will be the 1st part! Hope you enjoy!

This guide aims to provide you with a foundational understanding of human growth hormone (HGH) and its intelligent application in bodybuilding. While it doesn't cover every detail, it offers enough insight to help you design your own cycle. I’m sharing this from the perspective of someone with ten years of personal experience using HGH, including both self-experimentation and performance as an athlete.

Human Growth Hormone, also known as somatotropin (or rHGH), is produced by the pituitary gland and consists of a 191-amino acid chain. In youth, HGH is crucial for the proper development of bones, muscles, and tissues. A deficiency can lead to stunted growth, while excess can cause abnormal growth conditions.
As we age, HGH levels naturally decline, starting in our 30s. By the time we reach our 60s, daily HGH secretion may drop to just 10% of peak levels.
This decrease is linked to several signs of aging, such as:
• Increased body fat
• Decreased muscle mass
• Bad skin quality
• Reduced bone density
• Cognitive decline
• Decreased libido
• Poor overall well-being
• Sleep disturbances
• Feelings of depression and fatigue

Supplemental HGH can potentially mitigate these issues, often referred to as "the fountain of youth" due to its restorative benefits.

How is HGH Released in the Body?
HGH is secreted in pulses, mainly during sleep and following high-intensity exercise. Growth Hormone Releasing Hormone (GHRH) from the hypothalamus stimulates its release, while somatostatin inhibits it. Additionally, ghrelin, produced in the stomach, plays a role in stimulating HGH release.
Once released, HGH acts quickly, typically within 30 minutes, prompting the liver and other tissues to secrete Insulin-like Growth Factor 1 (IGF-1), which is instrumental in muscle growth and fat metabolism.
Mechanism of Action
HGH has both direct and indirect effects. It binds to receptors on fat and muscle cells, promoting fat breakdown and supporting muscle protein synthesis. Indirectly, through IGF-1, it stimulates the growth of bone and muscle tissues.
HGH also influences other hormones, such as insulin, which can lead to altered glucose metabolism. Users should be aware of potential changes in insulin sensitivity and consider monitoring their metabolic response.
Conclusion and Call to Share Experiences
This overview highlights the potential of HGH as a tool for enhancing muscle growth and overall health. However, individual responses can vary significantly. I encourage others to share their experiences with HGH—what has worked for you, any challenges faced, and insights gained along the way? Your stories can provide valuable information to those considering its use.

Thanks for reading! The next part is coming!
 
I’ve been using HGH on and off for the last 2 years. For me, the main benefit has been increased fat loss and improved sleep. I haven’t noticed massive muscle growth, but my recovery from training is noticeably better, and I have a lot more stamina. One thing I’d recommend is getting your hormone levels checked regularly to ensure you're staying in a healthy range. Too much HGH can definitely lead to unwanted side effects like carpal tunnel syndrome or joint pain. Always stay on top of that!
 
For anyone who’s used HGH with a focus on anti-aging, how long did it take before you started seeing noticeable improvements?
 
I’ve experimented with HGH cycles along with other compounds like testosterone and peptides. The biggest difference I noticed was in my fat loss and muscle quality, but not so much in mass gain. HGH helped me lean out while still maintaining my strength. I also experienced better skin elasticity and joint relief, which was a big bonus. That being said, I wouldn’t say it’s a “magic bullet.” If you’re looking for quick gains in size, I’d recommend stacking it with other compounds. However, if you're more about overall health and longevity, HGH is definitely worth considering.
 
BennyTheBeast said:
Has anyone had issues with insulin sensitivity while using HGH?
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Yeah, some people definitely run into insulin sensitivity issues when using HGH. The stuff can boost your IGF-1 levels, which messes with how your body handles carbs and can lead to insulin resistance. If you’re already someone who’s a bit prone to that, like with pre-diabetes or anything, it can make things worse. It's smart to keep an eye on your blood sugar, especially if you’re using HGH for a while. Get regular blood tests and check in with a doctor to stay on top of it. Also, dialing in your diet and workouts is key — good nutrition and staying active can help keep your insulin sensitivity in check.
If you start noticing issues with insulin or other weird side effects, it’s a good idea to chat with a doc about adjusting your HGH use or other supps.
 
chrisTheChemist said:
Yeah, some people definitely run into insulin sensitivity issues when using HGH. The stuff can boost your IGF-1 levels, which messes with how your body handles carbs and can lead to insulin resistance. If you’re already someone who’s a bit prone to that, like with pre-diabetes or anything, it can make things worse. It's smart to keep an eye on your blood sugar, especially if you’re using HGH for a while. Get regular blood tests and check in with a doctor to stay on top of it. Also, dialing in your diet and workouts is key — good nutrition and staying active can help keep your insulin sensitivity in check.
If you start noticing issues with insulin or other weird side effects, it’s a good idea to chat with a doc about adjusting your HGH use or other supps.
Click to expand...
Thanks for the explanation!
 
IronBender said:
I’ve been using HGH on and off for the last 2 years. For me, the main benefit has been increased fat loss and improved sleep. I haven’t noticed massive muscle growth, but my recovery from training is noticeably better, and I have a lot more stamina. One thing I’d recommend is getting your hormone levels checked regularly to ensure you're staying in a healthy range. Too much HGH can definitely lead to unwanted side effects like carpal tunnel syndrome or joint pain. Always stay on top of that!
Click to expand...
A lot of people expect crazy muscle gains from HGH, but it’s really more about enhancing what you’re already doing.
And yeah, bloodwork is key. Too many guys skip that part and end up dealing with numb hands, water retention, or worse. Smart call staying on top of your health while using it.
 
BeastMode said:
How about combining HGH with peptides? Any tips?
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Stacking HGH with peptides like Ipamorelin or CJC-1295 (no DAC) can work well — you get the steady baseline from HGH and natural GH pulses from the peptides. It’s a solid combo for recovery, fat loss, and preserving insulin sensitivity if done right.
Tips:
  • Keep HGH low to moderate (1–3 IU/day)
  • Use peptides pre-bed or post-workout on an empty stomach
  • Watch for overlap — too much GH = sides (bloat, numbness, etc.)
  • Cycle off peptides every few months to avoid desensitization
Great stack if you respect the dosing and support it with proper diet, sleep, and bloodwork.
 
bigDogLifting said:
For anyone who’s used HGH with a focus on anti-aging, how long did it take before you started seeing noticeable improvements?
Click to expand...
I’ve been using low-dose HGH (1–2 IU/day) for anti-aging purposes for a little over a year now. For me, the first noticeable changes showed up around 6–8 weeks in — better sleep, improved skin texture, and more stable energy throughout the day.
The more subtle stuff like joint comfort, mood, and faster recovery took 3–4 months to really kick in. Nothing dramatic overnight, but it builds up steadily if your training, diet, and sleep are dialed in.
Consistency is key, and bloodwork helps track progress. It’s a slow burn — but worth it if you’re patient.
 
MikeT22 said:
I’ve experimented with HGH cycles along with other compounds like testosterone and peptides. The biggest difference I noticed was in my fat loss and muscle quality, but not so much in mass gain. HGH helped me lean out while still maintaining my strength. I also experienced better skin elasticity and joint relief, which was a big bonus. That being said, I wouldn’t say it’s a “magic bullet.” If you’re looking for quick gains in size, I’d recommend stacking it with other compounds. However, if you're more about overall health and longevity, HGH is definitely worth considering.
Click to expand...
Solid take — totally matches my experience. HGH shines more for body recomposition, recovery, and longevity, not blowing up in size. I noticed the same: tighter skin, better joints, and staying lean while keeping strength.
And yeah, it’s definitely not a magic bullet. People expecting mass-gain miracles are usually disappointed unless they're stacking it right and already dialed in. But for long-term health and quality muscle, it’s one of the better tools out there when used smart.
Appreciate the honest breakdown!
 
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